Chemical-specific adjustment factors for interspecies differences and human variability : guidance document for use of data in dose/concentration-response assessment.
Publication details: Geneva : World Health Organization, 2005. Description: iii, 96 p. : ill. ; 29 cmISBN: 9241546786Subject(s): No-observed-adverse-effect level | Chemicals | Variation (Genetics) | Species specificity | Risk assessment | GuidelinesNLM classification: QV 602 C 2005 Summary: The objective of this document is to provide guidance to risk assessors on the use of quantitative toxicokinetic and toxicodynamic data to address interspecies and interindividual differences in dose/concentration-response assessment. Section 1 focuses on the relevance of this guidance in the context of the broader risk assessment paradigm and other initiatives of the International Program on Chemical Safety (IPCS) project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals. Technical background material is presented in section 2, followed by generic guidance for the development of chemical-specific adjustment factors in section 3 and accompanying summary figures. Illustrative case-studies are included in an Appendix and a glossary of terms is also provided.| Item type | Current library | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|
Books
|
FNPH LIBRARY | QV 602 C 2005 (Browse shelf(Opens below)) | Available | 03581 |
Browsing FNPH LIBRARY shelves Close shelf browser (Hides shelf browser)
| No cover image available | ||||||||
| QV 600 T 2010 A textbook of modern toxicology. | QV 600 W 2010 WHO human health assessment toolkit : | QV 602 C 2005 Chemical-specific adjustment factors for interspecies differences and human variability : | QV 602 C 2005 Chemical-specific adjustment factors for interspecies differences and human variability : | QV 602 I 2007 IPCS mode of action framework. | QV 602 I 2007 IPCS mode of action framework. | QV 602 P 2005 Principles of characterizing and applying human exposure models. |
The objective of this document is to provide guidance to risk assessors on the use of quantitative toxicokinetic and toxicodynamic data to address interspecies and interindividual differences in dose/concentration-response assessment. Section 1 focuses on the relevance of this guidance in the context of the broader risk assessment paradigm and other initiatives of the International Program on Chemical Safety (IPCS) project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals. Technical background material is presented in section 2, followed by generic guidance for the development of chemical-specific adjustment factors in section 3 and accompanying summary figures. Illustrative case-studies are included in an Appendix and a glossary of terms is also provided.
There are no comments on this title.