TY  - BOOK
AU  - Friedman,Lawrence M.
AU  - Furberg,Curt
AU  - DeMets,David L.
TI  - Fundamentals of clinical trials 
SN  - 0387985867
PY  - 1998///
CY  - New York
PB  - Springer
KW  - Clinical trials
KW  - Clinical Trials
KW  - Research Design
N1  - Includes bibliographical references and index
N2  - The randomized control clinical trial has become the goal standard scientific methods for the evaluation of pharmaceuticals, biologics, devices, procedures,and diagnostic tests. This trial design has been successfully used in both therapeutic and disease prevention trials.  It is superior to alternative design by eliminating several sources of bias which exist in those designs. This role has evolved over the past three decades in a number of disease area including cardiology, ophthalmology, cancer, and AIDS.  ,
ER  -